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Open Positions


Postdoctoral fellow

Three postdoctoral associate positions are available in the newly formed laboratory of Dr. Zuzana Keckesova at Institute of Organic Chemistry and Biochemistry (IOCB) at Czech Academy of Science in Prague, Czech Republic. IOCB is a renowned interdisciplinary scientific institute with a blend of highly qualified and innovative chemists, biologists, biochemists and biophysicists that engage in frequent fruitful collaborations. It has developed a well refined infrastructure with many excellent core facilities and state-of-the-art equipment. The institute supports independent research, promotes the transfer of results from basic science to translational sphere and provides an inspiring environment for realization of top quality science.

The aim of Dr. Keckesova's lab is to identify and characterize new tumor suppressor pathways and circuitries in human cells with the ultimate goal of translating this new knowledge into therapeutic use. Dr. Keckesova's lab is researching tissues/cell types that rarely undergo tumorigenesis. These are the cellular models that already found a way to battle cancer and can teach us valuable lessons about tumor supressor circuitries that can be used in our fight against cancer. She recently published a scientific article in Nature elaborating on this topic.

We are looking for postdoctoral associates with background in: cancer biology, molecular biology, biochemistry. Also considered will be scientists from other areas that believe to be able to contribute to this project or bring in a new relevant expertise. We are looking for creative, imaginative, independent and highly-motivated applicants with experience in molecular biology/biochemistry methods and techniques. Bioinformatics and/or animal facility handling skills are a plus. Good English speaking skills are necessary. Institute is very multinational and main way of scientific communication is in English. Positions will be initially for 3 years with a possibility of extending to 5 years. Dr. Keckesova's lab is very well funded and offers above-average salary in Czech Republic. Selected postdocs will enjoy many of the benefits that the Institute provides. Starting date is flexible with the earliest date in September 2017.
Excellent opportunity for those of the applicants that are also looking for an adventurous mid-term stay and work in central Europe, with easy access to all other European countries. Prague is one of the most beautiful cities in the world and it offers a beautiful bohemian standard of living.

Interested candidates should submit their CV including names and contact information of two references and a brief description of their research experience via e-mail to keckesova@uochb.cas.cz

 



Senior Research Scientist in Structural Proteomics

We are looking for a highly competent and self-motivated research scientist in the area of mass spectrometry-based structural proteomics to run projects in our core facility lab as a collaborative support for the diverse life-science research projects at the Institute of Organic Chemistry and Biochemistry CAS (IOCB) in Prague, Czech Republic. The expected starting date for the appointment is September 1, 2017.

RESPONSIBILITIES

  • Development and application of methods for characterizing structure of proteins and their interactions (native MS, H-D exchange, chemical crosslinking etc.).
  • Collaborative and service support for the research projects at IOCB (see http://www.uochb.cz/web/structure/172.html for details).
  • Supervision, operation and maintenance of mass spectrometers (mainly Synapt G2, Orbitrap, TripleTOF).

REQUIREMENTS
Education/Skills

  • Ph.D. in science.
  • Substantial knowledge and working experience with advanced mass spectrometry technologies (Q-TOF, Orbitrap, TOF/TOF) and chromatography.
  • Know-how in mass spectrometry-based structural proteomics (e.g. native MS, H-D exchange, chemical crosslinking etc.).
  • Knowledge and experience in data processing and evaluation.

Personal

  • Ability to effectively interact with research and technical staff in a team-oriented manner, ability to suggest and discuss experimental strategies with life-science research groups.
  • Highly motivated, result-focused, autonomous and organized person.

OFFER

  • A dynamic and international state-of-the-art working environment in one of the birthplaces of modern antiretrovirals, set in a vibrant and modern metropolitan capital.
  • Competitive salary commensurate to skills and experience.
  • Fixed-term contract for 2 years with expected renewal.

APPLICATIONS
For further information please contact the Head of Mass Spectrometry Dr. Josef Cvačka directly by e-mail at cvacka@uochb.cas.cz. To apply, please send your CV, list of publications, motivation letter and contact details for 3 scientific references to the same address.

 

CLOSING DATE FOR THE APPLICATIONS IS July 15, 2017

 



Post-doc in Proteomics

We are looking for a highly competent and self-motivated postdoctoral researcher in the area of proteomics and mass spectrometry to run proteomics projects in our core facility lab as a collaborative support for the diverse life-science research projects at the Institute of Organic Chemistry and Biochemistry CAS (IOCB) in Prague, Czech Republic. The expected starting date for the appointment is September 1, 2017.

RESPONSIBILITIES

  • Development and application of MS-based proteomics methods for the identification, quantification and characterization of proteins as well as characterization of protein structure (HX-MS, XL-MS, etc.).
  • Collaborative and service support for the research projects at IOCB (see http://www.uochb.cz/web/structure/172.html for details).
  • Operation and maintenance of mass spectrometers (mainly TripleTOF, Synapt G2, Orbitrap).

REQUIREMENTS
Education/Skills

  • Ph.D. in science.
  • Substantial knowledge and working experience with advanced mass spectrometry technologies (Q-TOF, Orbitrap, TOF/TOF) and chromatography.
  • Know-how in qualitative and quantitative proteomics approaches.
  • Experiences in data analysis.

Personal

  • Ability to effectively interact with research and technical staff in a team-oriented manner, ability to suggest and discuss experimental strategies with life-science research groups.
  • Highly motivated, result-focused, autonomous and organized person.

OFFER

  • A dynamic and international state-of-the-art working environment in one of the birthplaces of modern antiretrovirals, set in a vibrant and modern metropolitan capital.
  • Competitive salary commensurate to skills and experience.
  • Fixed-term contract for 2 years with expected renewal.

APPLICATIONS
For further information please contact the Head of Mass Spectrometry Dr. Josef Cvačka directly by e-mail at cvacka@uochb.cas.cz. To apply, please send your CV, list of publications, motivation letter and contact details for 3 scientific references to the same address.

 

CLOSING DATE FOR THE APPLICATIONS IS July 15, 2017

 



Ph.D. / Postdoctoral position in Biochemistry

A Ph.D. / Postdoctoral position in Biochemistry is available in Dr. Jan Konvalinka’s lab at the IOCB Prague.


Hepatitis B virus infection represents a global health problem affecting millions people worldwide. Current therapies include nucleot(s)ide analogues that control but do not eliminate HBV infection. The key factor to this persistence is an intracellular HBV replication intermediate – covalently closed circular (ccc) DNA, which resides in the nucleus of infected cells as a non-integrated plasmid-like molecule and serves as a transcriptional template for HBV. Despite intensive research, the contribution of HBV proteins to the development and regulation of chronic infection is poorly understood and strategies for cccDNA degradation and elimination are limited. The successful candidate will be part of a research team studying mechanisms of cccDNA elimination. The project involves development of nanoparticles for delivery of CRISPR/Cas9 as well as development of other cell-based strategies targeting cccDNA.

IOCB is an excellent European institute with state of the art facilities and an international and stimulating atmosphere to accomplish your goals. Prague is an excellent place to live.

Requirements and how to apply: Motivated candidates must hold a Master degree or Ph.D. degree in the field of molecular biology or biochemistry. All the applicants should send their CV, motivation letter and contact details of two referees to Dr. Klára Grantz Šašková (saskova@uochb.cas.cz. The position is available from September 2017.

 



Postdoc / Research Associate – screening and diagnostics technology development

  • Are you a talented scientist with experience in biochemistry or molecular biology?
  • Do you want to contribute to the transition of basic research to real world applications?
  • Do you want to be a part of a dynamic team with entrepreneurial atmosphere?

Who we are
We have developed a novel proprietary assay called DIANA, which is suitable for ultrasensitive and selective enzyme detection and inhibitor screening (Navratil et al. 2017 in Nucl. Acids Res.). This multiwell plate based assay utilizing DNA-linked probe for target detection offers several unique advantages over existing approaches both in in vitro diagnostics and in early drug discovery. The commercial applications of the assay are being developed in collaboration with major industrial partners.
We are based in the laboratory of Jan Konvalinka at the Institute of Organic Chemistry and Biochemistry, Academy of Sciences in Prague. We greatly benefit from available expertise and excellent experimental facilities in the institute, which has a global reputation and strong record in drug discovery. We also plan to found a spin-off company in the near future in order to deliver our products to the market.

What responsibilities you will have
In this position, you will be a part of a multidisciplinary team that seeks further development of the DIANA assay for novel targets and for novel applications. You will be expected to deliver closely coordinated specific developmental tasks but you will also drive your independent research projects.
You will employ molecular biology methods, such as qPCR, molecular cloning, western-blotting, enzyme kinetics and multiwell plate based assays, as well as cell culture, protein expression and purification techniques. You will also contribute to protocol automatization and development of the assay to a standardized kit format.
While the main criteria of success is successful introduction of DIANA to diagnostics and screening markets, we also expect that you will author several research publications in high impact journals.

Who you are
You have a doctorate degree or 4 years of equivalent scientific experience in biochemistry, molecular biology or related field. You have experience with PCR, molecular cloning, recombinant protein expression, cell culture and working with antibodies. Experience with immunoassays such as ELISA and/or research background in kinases, methyltransferases or GPCRs is a plus.
You are friendly, enthusiastic, team oriented and skilled person with a strong inner drive. You are organized and able to plan and conduct your work independently and to take responsibility for end-to-end delivery of developmental projects. You are not afraid to work on multiple challenges in parallel and at the same time, you pay attention to details. Your fluent English and strong communication skills enables you to facilitate research collaborations. You are motivated to contribute to the technology development and interested to work on an interface of academic and applied research.

The position is available starting immediately. You will be offered a competitive salary with an initial 1-year contract, which can be later extended for another 1-2 years. You will also get an opportunity to join a newly established company.

We are looking forward to receiving your motivation letter and CV (incl. list of publications and two reference contacts) to vaclav.navratil@uochb.cas.cz.

 



A Ph.D. position in Biochemistry

is offered at the Institute of Organic Chemistry and Biochemistry, Czech Academy of Sciences in Prague, Czech Republic.


The multidisciplinary project deals with the study on insulin storage forms in pancreatic secretory granules. The project should provide the first insight into the structural forms of insulin present in pancreatic cells and elucidate the role of their endogenous chemical components in regulation of insulin storage, release and physiology. The project should also decipher some strategies for modulation of insulin release from pancreatic beta-cells by small molecule ligands.

The student will work in Jiří Jiráček’s Group, which is engaged in structure-activity studies of insulin and insulin-like growth factors 1 and 2. IOCB Prague is an excellent European institute with state of the art facilities and an international and stimulating atmosphere to accomplish your goals. Prague is an excellent place to live.

Requirements and how to apply:
Motivated candidates must hold a Master degree in the field of molecular biology, biochemistry or organic chemistry. All the applicants should send their CV, motivation letter and contact details of two referees to Dr. Jiří Jiráček (✉: jiracek@uochb.cas.cz). The position is available from September 2017.

 



Postdoc position - IOCB Prague

Job description (Projects):

  • Development of a molecular toolkit for control and investigation of the bacterial stringent response
  • Development of novel antibacterials termed lipophosphonoxins
  • Design and synthesis of azanuceloside phosphonates and -boronates as inhibitors of 6-oxopurine phosphoribosyltransferases and their prodrugs as potential drugs against malaria and tuberculosis.

Requirements:

  • Ph.D. in Organic chemistry (synthesis, separation techniques, characterization – NMR, MS, LC-MS, IR..)
  • English language

Salary: 36 000 CZK (Gross)

Start date: April 2017

Benefits:

  • Employee benefits
  • Extra week of vacation
  • Walking distance from Metro station Dejvická

How to apply: Motivation letter and CV should be sent to Dr. Dominik Rejman (rejman@uochb.cas.cz).

 



Master / Ph.D. student - Ion Channels in Neurological Disorders

The Ion Channels and Diseases lab of Dr. Norbert Weiss (www.theweisslab.com) at the Institute of Organic Chemistry and Biochemistry in Prague, Czech Republic, is looking for a motivated Master/PhD student interested in studying the molecular and cellular basis of neuronal disorders linked to calcium channels. The project involves functional analysis of calcium channel activity in cell lines and primary neurons by patch-clamp electrophysiology, confocal microscopy, in combination with various techniques of molecular biology and biochemistry.

Work in the lab focuses on the molecular physiology of T-type calcium channels, with an emphasis on elucidating the molecular mechanisms and actors controlling their trafficking to the cell surface, in normal and pathological conditions.

The lab is located at the Institute of Organic Chemistry and Biochemistry (www.uochb.cz), which is a leading and interdisciplinary research center with international faculty and students.

Your profile
The position will be available starting as immediately as February 2017 and is open for Master and Ph.D. students in a relevant field (neuroscience, biology), and ideally prior experience in patch clamp electrophysiology. Interested candidates should send their curriculum vitae, a description of their scientific interest and the name and contact information of up to three references who are able to comment on your academic background to weiss@uochb.cas.cz. A good command in English is a requirement. We are looking forward to receiving your application.

 



Research and development specialist/Technician (Dr. F. Teplý group)

Job description:

  • We develop inhibitors of expression of c-myc gene, which is decisive for the majority of oncologic disorders. The inhibitory effect is based on stabilization of secondary structures in the promoter of c-myc gene.
  • The work will include analysis of substances in vitro by polymerase stop method (radioactive version), FRET melting and thermophoresis. Best compounds will be further tested in selected cell lines (toxicity, analysis of the expression level of mRNA and protein).

We offer:

  • Interesting work in interdisciplinary research environment focused at developing new anticancer drug candidates.
  • Work in a young and dynamic international team on the border of medicinal chemistry, biochemistry and pharmacology.
  • Support for continuing education and personal growth (courses).
  • Work contract (full-time employment) for 1 year with possibility of extension for three years.
  • Place of work: IOCB, CAS, Prague 6.

Requirements:

  • University degree (Mgr., Ing., or Bc.) in biochemistry, molecular biology, pharmacology or related field.
  • Reliability, responsibility, flexibility.
  • Willingness to learn new methodological procedures, manual skills, a positive attitude to science and research (internal motivation).
  • Knowledge of English and good computer skills (MS Office).
  • The position is suitable for fresh graduates, laboratory experience is an advantage.

How to apply:

  • Motivation letter and CV should be sent to Dr. Filip Teplý (teply@uochb.cas.cz).
  • Possible start immediately.

 



Postdoctoral position in Biochemistry/Structural Biology: Prague, Czech Republic

We are seeking a highly motivated individual who is willing to accept the challenge of cutting edge research at the interface biochemistry/structural biology of G-quadruplexes.

Job Description: This project is focused mainly at c-myc G-quadruplex and will also involve evaluation of small molecule ligands using techniques of biochemistry/molecular biology. Successful applicant for this postdoc position will be an outstanding self-driven person who will primarily explore the crystallizations of promoter G-quadruplexes with small molecule ligands. The aim is to elucidate molecular details of their interaction. Innovative crystallization approaches will be pursued. Located in the stunning city of Prague, our research facilities comprise a state-of-the-art instrumentation portfolio.

Requirements: Applicant must have Ph.D. in biology, biochemistry or a closely related discipline. The candidates must be a first author on at least 2-3 publications. This position requires prior experience in biochemistry and structural biology techniques. Excellent oral and written communication skills in English are required as well as the ability to conduct independent scientific investigations. Position is for one year with possible extension.

How to apply: Please submit cover letter, CV, and contact information for 2-3 references combined into one PDF file by e-mail to: teply@uochb.cas.cz and rezacova@uochb.cas.cz

Contacts:
Filip Teplý, Ph.D. and Pavlína Řezáčová, Ph.D.
Institute of Organic Chemistry and Biochemistry CAS, v.v.i.
Flemingovo nám. 542/2
166 10 Prague 6
Czech Republic
✉: teply@uochb.cas.cz / rezacova@uochb.cas.cz