List of current scientific projects and collaborations:

  • Controlling Structure and Function of Biomolecules at the Molecular Scale: Theory Meets Experiment
    Participation in a Center of Excellence – PI Prof. Pavel Hobza, IOCB
  • Cathepsin Proteases in Pathology
    Collaboration with Michael Mareš’ Group at IOCB and Center for Drug Discovery, University of California San Francisco, U.S.A.
  • Glutamate Carboxypeptidase II (GCPII) a.k.a. Prostate Specific Membrane Antigen (PSMA) Related Projects
    • Polymer Bound GCPII Ligands for Targeted Drug Delivery
      Collaboration with Jan Konvalinka, IOCB and Karel Ulbrich, Institute of Macromolecular Chemistry AS CR
    • Prodrugs of 2-Phosphonomethyl Pentanedioic Acid (PMPA) a Potent yet Orally Non-Available Inhibitor of Glutamate Carboxypeptidase II (GCPII)
      Collaboration with Marcela Krečmerová, IOCB and Barbara Slusher, Brain Science Institute, Jonhs Hopkins University, Baltimore, U.S.A.
  • Biogenesis Of (E)-1-Nitropentadec-1-ene In Soldiers Of The Termite Genus Prorhinotermes
    Collaboration with Robert Hanus, IOCB
  • Development of Protein Delivery Systems Suitable for Cell Reprograming of Non-Endorine Pancreatic Cells into the Insulin Producing β-Cells
    Collaboration with with Tomáš Koblas and František Saudek, Institute for Clinical and Experimental Medicine (IKEM), Prague
  • Design, Characterization and Mechanism of Action of Novel Inhibitors of HIV Assembly
    Participation on collaborative project with Jan Konvalinka, IOCB and Aleš Machara, Department of Organic Chemistry, Faculty of Science, Charles University, Prague
  • Synthesis of Novel Biradicaloid Heterocycles Small Chromophores with Efficient Singlet Fission
    Collaboration with Josef Michl and Zdeněk Havlas, IOCB